A first-half double from Angel di Maria capped a superb Paris Saint-Germain performance as they downed Real Madrid 3-0 in the Champions League while Atletico Madrid struck late to draw 2-2 with Juventus on Wednesday.
Zinedine Zidane's Real offered only occasional resistance while PSG, even without suspended Neymar and injured Kylian Mbappe, missed several chances before Thomas Meunier added an injury-time third.
They top Group A after Club Brugge drew 0-0 with Galatasaray.
Cristiano Ronaldo returned to Spain with Juventus but it was Juan Cuadrado and Blaise Matuidi who scored for the Turin side before Stefan Savic and Hector Herrera rescued a last-gasp point for Atletico.
Bayer Leverkusen lost 2-1 to Lokomotiv Moscow in the other Group D contest.
Manchester City cruised 3-0 at Shakhtar Donetsk in Group C and Atalanta crashed in their first-ever Champions League game 4-0 at Dinamo Zagreb.
In Group B, Bayern Munich beat Socceroos star Milos Degenek's Red Star Belgrade 3-0 and last season's beaten finalists Tottenham Hotspur drew 2-2 at Olympiacos.
It was a tough night in Munich for Degenek, who once again played at the heart of the visitors' defence.
Apart from conceding goals to Kingsley Coman (34th), Robert Lewandowski (80th) and Thomas Mueller (91st), Degenek also received a caution.
PSG needed only 14 minutes to open the scoring when Di Maria poked home at the near post and the Argentina midfielder soon found the corner from 20 metres to double the lead.
Gareth Bale immediately replied with a wonder goal of his own which was correctly disallowed for handball and Karim Benzema also had a strike ruled out after the break.
But these were occasional positive moments for the record 13-time European champions who ended the game without an official shot on target.
"We had opportunities tonight," said Real midfielder Casemiro. "We scored two 'goals' which didn't stand but we can't have any excuses."
PSG spurned various opportunities but Meunier, combining with Juan Bernat, put the icing on the cake in injury-time.
"There's no message sent, but we dominated this game very well," PSG captain Thiago Silva told RMC Sport. "We were very efficient and solid, which we needed to be."
Juventus have high hopes of finally ending a Champions League drought dating since 1996 and a great finish from Cuadrado, plus a header from Matuidi put them in front in Madrid.
Atletico soon replied through Savic and Herrera powered in from a corner for a last-minute equaliser against the side who eliminated them last year.
"I think we played well but we have a bitter taste in our mouth now because we felt we had the game in our hands," said Juve coach Maurizio Sarri.
Spurs blew a two-goal advantage at Olympiacos having led through Harry Kane's penalty and Lucas Moura.
However, Daniel Podence pulled one back before half-time and Mathieu Valbuena levelled from the spot early in the second period to earn the Greeks a deserved point.
Pep Guardiola's City had little trouble in dismissing Shakhtar on goals from Riyad Mahrez, Ilkay Guendogan and Gabriel Jesus.
Australian Associated Press